Compound identity
- Designation
- MOTS-c (mitochondrial open reading frame of the 12S rRNA-c)
- Class
- Mitochondrial-derived peptide (MDP)
- Sequence
- Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg (MRWQEMGYIFYPRKLR)
- Molecular formula
- C101H152N28O22S2
- Molecular weight
- approx. 2174.6 g/mol (free peptide)
- CAS number
- 1627580-64-6
Nomenclature and identity
MOTS-c belongs to a small family of mitochondrial-derived peptides, short open reading frames in the mitochondrial genome that are translated into bioactive peptides. Other members include humanin and the SHLP series. MOTS-c was first reported in 2015 as being encoded within the 12S rRNA region.
The synthetic peptide contains two methionine residues and one tryptophan, which makes it susceptible to oxidation. Mass spectrometry readily shows +16 Da oxidation variants, and these should be considered when interpreting identity data.
What the published literature examines
Reviews describe MOTS-c research in cultured cells and rodent models, focusing on AMPK-related signaling, cellular responses to metabolic and oxidative stress, and reported nuclear translocation under stress conditions. A 2023 review in the Journal of Translational Medicine (Wan et al.) summarizes reported effects and proposed mechanisms related to stress, metabolism, and aging biology. A 2023 review in Frontiers in Endocrinology (Zheng et al.) surveys the same body of preclinical work from a translational-research perspective.
These reviews draw largely on preclinical data. They discuss proposed mechanisms and open questions; they do not establish clinical outcomes.
Analytical and research considerations
With four basic residues (three Arg and one Lys), MOTS-c is strongly cationic, which affects retention in reversed-phase HPLC and can promote adsorption to some plastics and glass surfaces at low concentrations. Oxidized methionine species and deletion sequences are the impurity classes most often seen.
Lot documentation that reports both HPLC purity and a mass-spectrometry identity confirmation is more informative than purity alone, because oxidized variants may co-elute near the main peak.
What a Certificate of Analysis can and cannot establish
A lot COA can
- Confirm that the tested lot matches the expected identity by an orthogonal method such as mass spectrometry.
- Report chromatographic purity (typically HPLC area percent) for that specific lot at the stated test date.
- Tie results to a lot or batch number that can be matched against the vial label.
A lot COA cannot
- Describe any lot other than the one tested, or material after the stated test date.
- Establish biological activity, safety, or suitability for any experimental model.
- Substitute for a researcher's own incoming-material verification where a study design requires it.
Current report status for every catalog item is listed in the Certificate of Analysis library. See also how to read a peptide COA.
Selected independent literature
- Mitochondria-derived peptide MOTS-c: effects and mechanisms related to stress, metabolism and aging.Wan W et al. J Transl Med, 2023. PubMed ID 36670507.Review of reported effects and proposed mechanisms in preclinical systems.
- MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation.Zheng Y et al. Front Endocrinol (Lausanne), 2023. PubMed ID 36761202.Review surveying preclinical MOTS-c research and open translational questions.
Literature is cited for scientific context only. Neon Valley Research did not author these publications, and their findings are not claims about any product.
MOTS-c 10 MG
16-amino-acid Mitochondrial-Derived Peptide. Supplied as 10 mg / vial.
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Related research references
- NAD+ research referenceNicotinamide adenine dinucleotide in its oxidized form, a ubiquitous coenzyme in redox metabolism and a substrate for NAD+-consuming enzymes.
- BPC-157 research referenceA synthetic 15-residue peptide whose sequence is derived from a fragment described in gastric juice protein studies.
RESEARCH USE ONLY – NOT FOR HUMAN OR ANIMAL USE. This reference is provided for laboratory and analytical research context only. It is not guidance for any human or animal use.