Compound identity
- Designation
- KPV (Lys-Pro-Val)
- Class
- Synthetic tripeptide; α-MSH(11–13) fragment
- Sequence
- L-Lysyl-L-prolyl-L-valine
- Molecular formula
- C16H30N4O4
- Molecular weight
- approx. 342.4 g/mol (free peptide)
- CAS number
- 67727-97-3
Nomenclature and identity
Alpha-MSH is a 13-residue peptide derived from proopiomelanocortin (POMC). Its C-terminal Lys-Pro-Val sequence attracted research interest after studies reported activity for this short fragment in inflammation-related cell models. The synthetic tripeptide is often written "KPV" from its one-letter codes, and is sometimes supplied as an acetate salt.
Its small size makes identity confirmation by mass spectrometry straightforward. Stereochemistry matters: the D-valine analogue (often written KdPV) appears in the literature as a separate compound and should not be confused with the all-L form.
What the published literature examines
A 2008 review in Endocrine Reviews (Brzoska et al.) covers α-MSH and related tripeptides, including KPV and KdPV. It discusses their biochemistry, anti-inflammatory and protective effects reported in vitro and in animal models, and the authors' perspectives on future research directions. The review notes that the tripeptides' mechanisms may differ from those of full-length α-MSH at melanocortin receptors. This remains an area of active investigation.
Later literature examines KPV in cell-culture systems, including intestinal epithelial and immune cell models, and in nanoparticle delivery studies. Findings come from preclinical systems.
Analytical and research considerations
Very short, hydrophilic peptides elute early in reversed-phase HPLC and can be hard to separate from synthesis by-products and counter-ions. Method details such as the column, ion-pairing agent, and detection wavelength strongly affect reported purity and should accompany the value.
Chiral purity (L- versus D-valine) is not resolved by standard achiral HPLC. Where stereochemistry matters to a study, a chiral method or supplier statement of stereochemistry is required.
What a Certificate of Analysis can and cannot establish
A lot COA can
- Confirm that the tested lot matches the expected identity by an orthogonal method such as mass spectrometry.
- Report chromatographic purity (typically HPLC area percent) for that specific lot at the stated test date.
- Tie results to a lot or batch number that can be matched against the vial label.
A lot COA cannot
- Describe any lot other than the one tested, or material after the stated test date.
- Establish biological activity, safety, or suitability for any experimental model.
- Substitute for a researcher's own incoming-material verification where a study design requires it.
- Confirm stereochemical purity unless a chiral method is reported.
Current report status for every catalog item is listed in the Certificate of Analysis library. See also how to read a peptide COA.
Selected independent literature
- Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivo, and future perspectives for the treatment of immune-mediated inflammatory diseases.Brzoska T et al. Endocr Rev, 2008. PubMed ID 18612139.Review of α-MSH and related tripeptides (including KPV) in vitro and in animal models.
Literature is cited for scientific context only. Neon Valley Research did not author these publications, and their findings are not claims about any product.
KPV 10 MG
Lys-Pro-Val Tripeptide. Supplied as 10 mg / vial.
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Related research references
- BPC-157 research referenceA synthetic 15-residue peptide whose sequence is derived from a fragment described in gastric juice protein studies.
- GHK-Cu research referenceThe copper(II) complex of the tripeptide glycyl-L-histidyl-L-lysine.
RESEARCH USE ONLY – NOT FOR HUMAN OR ANIMAL USE. This reference is provided for laboratory and analytical research context only. It is not guidance for any human or animal use.